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In JANUMET-treated patients with a diagnosis or strong suspicion of lactic acidosis, prompt hemodialysis is recommended to correct the acidosis and remove accumulated metformin (metformin HCl is dialyzable, with a clearance of up to 170 mL/min under good hemodynamic conditions)
Potential changes include enlarged jaw, hands, feet, and internal organs
Zinc: Zinc is involved in numerous bodily functions, including the production of melatonin
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