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GLP-1 receptor stimulation can increase dopaminergic neuron activity via a presynaptic mechanism of action in the ventral tegmental area (VTA) (21) and increase the expression of dopamine transporter on the neuronal cell surface to reduce free dopamine levels in the synapses in LS and striatal brain (22, 23)

The FDA said primary violations communicated in the letters included claims suggesting equivalence with FDA-approved products and misleading branding practices