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The 16S rRNA gene V3-V4 region was amplified using a primer overhanging adapter (forward = 5-TCGTCGGCAGCGTCAGATGTGTATAAGAGACAGC CTACGGGNGGCWGCAG-3 and reverse = 5-GTCTCGTGGGCTCGGAGATGTGTATAAGAG ACAGGACTACHVGGGTATCTAATCC-3)

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