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The weight effect runs through several parallel mechanisms: it activates satiety centers in the hypothalamus so patients feel full sooner and stay full longer, it slows gastric emptying, it modulates reward pathways so calorie-dense foods feel less compelling, and it stabilizes post-meal glucose and insulin
Obes Surg 28:35533558 Bonnet JB et al (2024) Semaglutide 2.4 mg/wk for weight loss in patients with severe obesity and with or without a history of bariatric surgery
Hepatic steatosis is further aggravated by impaired fatty acid oxidation in an ethanol-impaired liver (79)
This comprehensive approach is what separates medically supervised weight loss from generic online programs
