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Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]
In patients with type 2 diabetes and CKD, SGLT2 inhibitors are generally superior to GLP1 receptor agonists in preventing progression to kidney failure (KRT/ESKD), slowing eGFR decline, reducing albuminuria, and lowering cardiovascular events and mortality
Richmond said she'd be concerned about how people might react when the effects plateau or if they're no longer taking the drug
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