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Personal Preference for Maintenance: Once acute deficiency symptoms are managed, some patients may prefer to switch to oral supplements for ongoing maintenance, again, strictly under medical supervision to ensure their levels remain stable

However, in a much larger randomized controlled trial of simvastatin and an antioxidant combination of 600 mg of all - rac --tocopherol (297 mg of RRR --tocopherol), 250 mg of vitamin C, and 20 mg of -carotene daily) in more than 20,000 men and women with CHD or diabetes mellitus, the antioxidant combination did not adversely affect the cardioprotective effects of simvastatin therapy over a five-year period (131)

Nature 468 , 11151118 (2010)