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/ 4-Methylumbelliferyl α-N-glycolylneuraminic acid / 4-Methylumbelliferyl-N-glycolyl-α-D-Neuraminic Acid (sodium salt)
including applications in enzyme replacement therapy (ERT) for lysosomal storage disorders and in lysosome-targeting chimera (LYTAC) approaches for targeted protein degradation
including galectins and other carbohydrate-binding lectins
Peracetylated)
AG612000: α-D-Man-Methyl-Carboxylic Acid (Peracetate) Pack Size:50 mg / 4-Methylumbelliferyl α-N-glycolylneuraminic acid /C16H22O12 406. 34 A peracetylated D mannose ligand equipped with a terminal carboxylic acid through a short methyl spacer. The carboxylic acid can be activated to NHS, sulfo NHS, or pentafluorophenyl (PFP) esters and reacted with amine functionalized platforms or lysine residues on proteins and peptides to form stable amide bonds. The sugar hydroxyl groups are protected as acetate esters (peracetate); these groups increase lipophilicity to facilitate
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