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The ability of BAT to regulate body temperature (thermogenesis) involves the uncoupling of proton flow in mitochondria
The mechanism appears to be interference with erythropoiesis
[9] For methylation-focused NNMT studies, stronger experimental designs may include SAM, SAH, SAM/SAH ratio, nicotinamide, 1-methylnicotinamide, NAD + , global DNA methylation, locus-specific DNA methylation, histone methylation markers, RNA expression profiling, and tissue-specific analysis where relevant
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