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Mechanisms Relevant to Dermal Research GHK-Cus documented effects in skin research include stimulation of collagen and glycosaminoglycan synthesis, modulation of matrix metalloproteinases and their inhibitors (TIMP-1 and TIMP-2), promotion of fibroblast migration and survival, and upregulation of VEGF and bFGF secretion by fibroblasts

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and (4) KyLO 25 , a laccase mutant from ascomycetous Myceliophthora thermophila engineered for enhanced activity at pH 8.0

In addition, the NAC group had significant improvements in self-reported levels of cognition and attention based upon their scores on the MHI cognition and PDQ attention subscores