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The critical requirement is a minimum of 48 hours between injections to avoid creating amplified drug peaks

Therefore, well-designed in vivo studies, incorporating long-term neuro-developmental follow-up, are essential to rigorously evaluate the therapeutic potential of L-carnitine/acetyl-L-carnitine in protecting the vulnerable developing brain following HIE (86)

Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]

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