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Pasireotides higher affinity to somatostatin receptor subtype 5 (SSTR5) and lower affinity to SSTR2 compared to first generation somatostatin analogs is presumed to result in a greater suppression of insulin secretion and lesser decrease in glucagon secretion (25)
Speak to your GP or diabetes care team about your concernsthey can help you find management strategies or adjust your treatment plan whilst maintaining effective glycaemic control
If you stop taking semaglutide without having solid lifestyle habits in place, it is common to regain some of the weight
However, increased potency requires vigilance
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