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2.2.1 Background PD is the second-most common neurodegenerative disorder after AD

Since the original measurement results were provided in Excel format, which is incompatible with the PRIDE database, the ProteinGroups.txt files generated by MaxQuant were used to recalculate the data and generate PRIDE-compliant files

The increased endothelial cell permeability is generated by TGF1 via SMAD3-dependent signaling, which upregulates matrix metalloproteinase-9 and downregulates claudin-5