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Participants were excluded if they met any of the following criteria: (1) age 5 pounds after initiating GLP-1RA experienced a TSH decrease of 0.360.55 mIU/L [29], and similar associations have been reported after bariatric surgery [25, 27, 67]
The best non-diabetic body-composition anchor favors tirzepatide, about 75:25 fat-to-lean loss in its DXA data versus about 62:38 in semaglutides. This is cross-trial evidence, not a head-to-head maintenance-dose DXA result
Often its about shaping the timing of the signal
The optimal dose often correlates with body mass, though the relationship is not perfectly linear
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