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Gastrointestinal symptoms dominate the side effect landscape
The cleavage of GIP(1-30)NH 2 subsequently results in GIP(3-30)NH 2 , a fragment that binds to the human GIP receptor with high affinity but does not have any intrinsic activation of the human GIP receptor in physiological concentrations ( Figure 1 The human GIP receptor can be found in multiple organs and tissues, reflecting its various physiological functions ( Beyond the pancreatic islet cells, the GIP receptor is expressed within the vascular system, including the heart and various endothelial cells
Rathgeber WF
That burning can outlast the other symptoms and interfere with sleep, because lying flat prolongs acid exposure
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