tirzepatide bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trial Obesity drug seen as effective

Results: Incidental SLD was overall associated with cardiovascular diseases: HR (CI) was 1.33 (1.15-1.54) for myocardial infarction, 1.24 (1.14-1.36) for coronary artery disease (CAD), 1.26 (1.12-1.46) for heart failure, and 1.17 (1.04-1.31) for stroke

However, there is a tachyphylactic effect over time with decreased delayed gastric emptying with longer drug use

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For instance, the immediate surge of free Fe during reperfusion drives lipid peroxidation mediated by ACSL4/Alox15, and the peroxidation of mitochondrial cardiolipin leads to the opening of the mitochondrial permeability transition pore (mPTP), resulting in ferroptosis of cardiomyocytes