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M.KaingS.van WerkhovenE.et al (2019)
It is thought that these mutations may minimize the FcR-mediated, HER2-independent uptake of ADC by normal tissues, thereby reducing off-target toxicity [63]
Alternate Sites: If rotating injection sites to prevent lipohypertrophy (tissue buildup), you may also use the outer thigh or upper arm fatty tissue
This creates a unique metabolic dance that the body needs time to adjust to, which is why the retatrutide dose schedule uses a gradual titration over many weeks
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