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These were predominantly dose-dependent and most prominent during dose escalation
However, in many other countries, including the United States, it is not approved by regulatory agencies for prescription or over-the-counter use
There are no symptoms or negative effects in early stages
The death of motor neurons results in a characteristic clinical feature: spasticity, muscular weakness and atrophy, hyperreflexia, cramps, fasciculation, Babinski sign, loss of coordination, paralysis of voluntary musculature, dysphagia and difficulties in swallowing, speech and respiration (Weiduschat et al., 2014
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