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During weight loss, the body reduces its resting metabolic rate as an evolutionary survival mechanism

PMID: 2 AmaralE

Oct 2012;21(4):605-610

Similarly, a recent systematic review and meta-analysis reported that GLP-1 RAs and glitazones most consistently reduced dementia risk among antidiabetic medications, while metformins effects were mixed and inconsistent, likely reflecting variability in study design, treatment duration, and confounding by indication 88