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SELECT (CV outcomes): The landmark 17,604-patient trial demonstrating 20% MACE reduction in overweight/obese adults with established CVD but without diabetes -- establishing semaglutide as the first anti-obesity medication with proven cardiovascular benefit

This difference in pharmacodynamics, as well as the differing half-lives, may contribute to the differences in efficacy seen in clinical trials

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By emitting a do not eat me signal, CD47 inhibits the phagocytic capacity of microglia toward both ferroptotic neurons and A plaques, leading to an immune-tolerant state