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Consistently, in mouse models of polycystic kidney disease nintedanib administration by intraperitoneal injections reduced cystic epithelial cell proliferation and cyst growth, and overall disease progression [223]
SCUBE2, signal peptide-CUB-EGF-like containing protein 2
This variant included an additional arginine residue and featured an elongated structure at the N-terminal (by 13 amino acids), resulting in a protein composed of 83 amino acids, compared to the 70 amino acids found in natural IGF-1
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