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First isolated from human plasma by Loren Pickart in 1973, GHK is a naturally occurring molecule: plasma levels sit around 200 ng/mL in young adults and decline steadily with age
Pickart, GHK-Cu has a very high uptake into human skin and is easily absorbed by passing through the lipids of the epidermal barrier
True allergy to hydroxocobalamin is rare but real, so a brief history matters
Interestingly, they found aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage
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