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KPVs tissue selectivity via PepT1 means its distribution profile differs meaningfully from the others, which is an argument for genuine non-redundancy and an equally good argument that its contribution in a systemic blend may not resemble its contribution in the mucosal models where it was characterised

What does science actually say, though

SAM, SAH, and Methylation-Balance Considerations NNMT uses SAM as a methyl donor and generates SAH, so NNMT activity is directly connected to the balance between methyl-donor availability and methylation-product accumulation

For chronic inflammatory conditions, the approach emphasizes sustained management over rapid resolution