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From a patient safety perspective, individuals should seek prompt medical advice if they experience: Severe or persistent abdominal pain (which may indicate pancreatitis) Right-upper-quadrant pain, fever, or jaundice (which may indicate a gallbladder problem) Rapid or irregular heartbeat Symptoms of hypoglycaemia, such as shakiness, sweating, or confusion Signs of an allergic reaction, such as rash, swelling, or difficulty breathing If you experience a suspected side effect from any medicine, you can report it to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk

There was a significant reduction in HOMA-IR during fasting as presented in Table 4

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Observational data have suggested lower all-cause mortality with GLP-1 RA use compared with other glucose-lowering therapies in advanced CKD (35)