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Cryo-EM structural studies (Li et al., Cell Discovery , 2024) resolved retatrutide's binding at all three receptor complexes, showing it is approximately 8.9 more potent at GIPR than native GIP but 0.30.4 as potent at GCGR/GLP-1R compared with the endogenous hormones [3]

Orforglipron showed stronger effects on blood sugar control, HDL cholesterol, and systolic blood pressure, while semaglutide showed larger effects on total body weight, waist circumference, and LDL cholesterol

Cardiovascular morbidity and mortality in rheumatoid arthritis

Each of these alternatives has its own risks and benefits which should be assessed with your healthcare provider to determine what is the best choice for you and your condition