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Quick Answer: Semaglutide may cause or worsen acid reflux symptoms in some patients by delaying gastric emptying, which increases intragastric pressure and can lead to retrograde flow of stomach contents into the esophagus
However, increased plasma glucose also reduces intercellular communication between endothelial cells and vascular smooth muscle cells (45, 70)
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Kupcova, V., Fedelesova, M., Bulas, J., Kozmonova, P
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