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However, gastroenterologist Eric Goldstein tells Insider, "What this illustrates is any medication, even when used appropriately, may have other changes or side effects that need to be monitored by the patient and the doctor." He also explained that having diarrhea after being constipated is called the "dam breaking phenomenon, which is what you'd expect from taking a ton of laxatives." Sometimes, the liquid stool can seep past the blockage, which is referred to as overflow or paradoxical diarrhea
Eriksson, J
Alternatively, switching entirely to tirzepatide (the GIP-1/GLP-1 receptor agonist) may work if your body has become desensitized to semaglutide's single-pathway approach
Neither trial showed primary-endpoint benefit
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