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In order to facilitate robust adhesion and/or transendothelial migration, these molecules interact with counter-receptors present on leukocytes and plasminogen activator inhibitor-1 within the circulatory system, indicating the potential presence of an endothelial phenotype that is both pro-inflammatory and pro-thrombotic (90)
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The absorbance at 490 nm was measured with a microplate reader
What the FDA Label and Guideline Documents Say The FDA prescribing information for evolocumab explicitly states: "Evolocumab is a human monoclonal antibody and is not expected to be metabolized by cytochrome P450 enzymes
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