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Approved medicines usually have defined indications, dosage forms, contraindications, warnings, and monitoring information
Experience employing dosing regimens from once-a-day to four-times-a-day, as well as studies in primate epilepsy models involving constant rate infusion, indicate that total daily systemic bioavailability (extent of absorption) is the primary determinant of seizure control and that differences in the ratios of plasma peak to trough concentrations between valproate formulations are inconsequential from a practical clinical standpoint
It also seems to have prevented the down-regulation of the IGF-I receptor and possibly inhibited apoptosis
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