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Serotonin Serotonin is synthesized through a two-step process involving a tetrahydrobiopterin-dependent hydroxylation reaction (catalyzed by tryptophan-5-monooxygenase, also called tryptophan hydroxylase) and then a decarboxylation catalyzed by DOPA decarboxylase (also known as aromatic L-amino acid decarboxylase)

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Patients taking other B-vitamin supplements or multivitamin preparations should inform their prescribing provider, as evaluation for potential additive effects or imbalances may be appropriate

Nat Rev Dis Primers (2019) 5:74