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Pharmaceuticals used to treat diabetes, schizophrenia, and other psychiatric diseases cause QTc prolongation
Tumors with inherited or somatic deficiencies in HRR genes, such as BRCA1, BRCA2, PALB2, and RAD51, exhibit synthetic lethality to PARPis, including olaparib, rucaparib, niraparib, and talazoparib, which have shown durable efficacy in BRCA-mutant breast, ovarian, and prostate cancers
FOXO4-DRI may support rejuvenation of endocrine tissue, muscle, and visceral declines associated with ageing
However, the synergy argument has biological plausibility: multiple compounds activating NRF2 through different pathways may require lower individual doses to achieve the same effect together
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