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These effects are likely primarily mediated through actions in various regions of the brain involved in the regulation of appetite and food intake [18], as supported by preclinical studies [19,20,21,22], multiple human imaging studies [18], and the GLP-1R expression patterns in the human brain [9, 23]
Unlike older weight-loss medications that simply suppress appetite through the central nervous system, GLP-1 agonists act on multiple pathways: Appetite regulation : They signal the brains satiety centre that you are full faster and for longer
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Gastroenterology and Hepatology 15, 625636
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