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(2005) in a randomized double-blind clinical study found that a 0.001% Pal-KTTKS formulation significantly reduced wrinkle depth and volume compared to vehicle control after 8 weeks of application

Importantly, it does not significantly stimulate ACTH, cortisol, or prolactin release at physiological doses (PMID: 9849822)

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association , 178 , 113935

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