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Acknowledgements The National Natural Science Foundation of China (NSFC) (grant number 82171575) and the Hubei Provincial Clinical Medical Research Center for Nephropathy (grant number OIR202402Z) were gratefully acknowledged

Selected Research Highlights GH/IGF-1 Axis: Used to probe pituitary output patterns and downstream signaling cascades associated with GH biology

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GLP-1 (glucagon-like peptide-1) is an endogenous hormone that plays a crucial role in regulating appetite, blood sugar levels, and digestion