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In brief, the first and rate-limiting step is the abstraction of a hydrogen atom by non-heme ferric iron (Fe(III)), involving a proton-coupled electron transfer in which the electron is transferred directly to the iron and the proton is acquired simultaneously by the hydroxide ligand in a concerted mechanism to give a substrate radical, while the iron atom is reduced to the ferrous state (Fe(II))
Drapeau, E
Factors such as ingredient quality, dosage, individual metabolism, and consistency of use all play a major role in the results
Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone
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