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The goal is to gently restart structure
When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases
Many patients with treatment resistant depression who supplement their SSRIs with methylfolate report improvements in the efficacy of their antidepressants (4)
R., Smiley, A., & Saadabadi, A
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