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Contraindications Tirzepatide is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, as well as those with a known allergy to the medication
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A 2021 analysis published in Cardiovascular Diabetology found that semaglutide produced significant reductions in triglycerides and total cholesterol alongside its weight loss effects, with improvements correlating strongly with the degree of weight lost (Husain et al., Cardiovascular Diabetology, 2021, Tirzepatide and Cholesterol: Does the Dual Mechanism Help More For patients with significant lipid abnormalities, tirzepatide may offer an advantage over semaglutide
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