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Methods: Male 8-12 wk old TG-IRE1 mice were treated with ip DOX (50 mg/kg) or saline for 4 or 48 hrs

Similar results were also observed in humans

To examine whether transient activation of LS GLP-1R neurons is sufficient to suppress feeding, we trained LS GLP-1R :ChR2 mice to consume Ensure on a fixed ratio 1 schedule, and photostimulation (20 Hz, 1.5 seconds) was synchronized with Ensure administration (Figure 5J)