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Similarly, exenatide ameliorated the inflammatory response in human RA FLSs by decreasing the oxidative stress capacity of FLSs and down-regulating the expression of IL-1 and IL-6, while suppressing the initiation of p38/MAPK and NF-B signal transduction pathways [240]
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Skin laxity refers to the loosening and sagging of skin that occurs when it loses its natural firmness and ability to bounce back. This common aesthetic concern can affect any area of the face or body, though its most noticeable in areas where the skin naturally has less underlying support, such as the neck, jawline and under-eye area
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