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Li X, Wang D, Liang J, Zhang H, Sun L
In CRPC, AR signaling upregulates inhibitory immune checkpoints (e.g., B7-H3) and proinflammatory cytokines (e.g., IL-6, TNF-), which recruit immunosuppressive cells and suppress T-cell function
These medications treat chronic conditionstype 2 diabetes and obesitythat typically need ongoing management
For example, a 70-year-old who is losing weight on semaglutide has a slower metabolism and reduced muscle protein synthesis compared to a 35-year-old on the same medication
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