glutathione and apoptosis

glutathione and apoptosis Targeting the Vulnerability of Metabolism in ARID1A-Deficient Cancers Glutathione Depletion Is Necessary for

Name: glutathione and apoptosis Targeting the Vulnerability of Metabolism in ARID1A-Deficient Cancers Glutathione Depletion Is Necessary for
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In ocular neovascular diseases, FSP1 modulates vascular endothelial cell proliferation/differentiation/migration to regulate pathological neovascularization and scar formation (105)

Key Takeaway: Excessive glutathione intake typically manifests as digestive upset or mineral imbalances

Besides inhibiting the Xc- antiporter, erastin is also an activator of the mitochondrial voltage-dependent-anion channel (VDAC) by reversing the inhibitory effect of tubulin on VDAC, thus increasing oxidative phosphorylation, ATP, ROS production and mitochondrial membrane permeabilization