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However, a retrospective cohort study published in Diabetes Care did find that use of GLP-1 medications for 1-3 years was associated with a slightly increased risk of all thyroid cancer (adjusted hazard ratio 1.58) and medullary thyroid cancer specifically (adjusted hazard ratio 1.78)

Nonetheless, both extraction approaches yielded polyphenol-rich extracts with promising applications as functional food additives and in pharmaceutical formulations (51)

No human clinical trials exist

Shan PR, Xu WW, Huang ZQ, Pu J, Huang WJ: Protective role of retinoid X receptor in H9c2 cardiomyocytes from hypoxia/reoxygenation injury in rats