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Recommended Timeline for Stopping Semaglutide Before Elective Surgery Most surgical guidelines recommend discontinuing semaglutide or other GLP-1 drugs between 24 and 72 hours before an elective procedure
32 Since tirzepatide does not have a GIP (3142) tail, chosen Ala 21 was likely to increase the GLP-1 activity, despite it slightly decreasing the GIP activity
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