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Guidelines and Expert Recommendations Major bone health organizations consistently recommend site-specific DXA for diagnosis and do not consider full-body scans interchangeable with those measurements: The International Society for Clinical Densitometry (ISCD) and the World Health Organization define osteoporosis based on central DXA sites

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The potential role of gut microbiome composition is a theoretical consideration that has not yet been substantiated by robust clinical evidence in this context

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Food supplements are not a substitute for a varied and balanced diet and a healthy lifestyle

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On the other hand, expression levels of hepatic Cpt1a, Ppara, Hmcs2 and Fgf21 , and circulating ketone bodies and FGF21 found highly elevated at 72 h in G49-treated mice are indicative of the contribution of FFA catabolism and ketogenesis to the lipid clearance

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