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Selecting the preserved formulation allows for multiple punctures over a 28-day beyond-use window post-opening, whereas the preservative-free formulation provides a pure, additive-free profile for high-dose or high-sensitivity applications
Subcutaneous injection bypasses all of these barriers except plasma half-life, which for unmodified small peptides is generally very short (minutes to low hours, based on class-level pharmacokinetic data for similar unmodified peptides)
Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy
Additional readouts (including next-generation sequencing, cell sorting, and imaging) applied to the cultured tissues will complement dynamic permeability measurements, thus providing a powerful approach for integrated investigations of hostmicrobiome interactions
