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This is, to our knowledge, the first large multicenter study directly comparing GLP-1 receptor agonists and bariatric surgery in this population. Using the TriNetX research database, Patel and colleagues identified patients with BMI 30 kg/m 2 or greater who between 2016 and June 2025 had catheter ablation for AF and subsequently underwent bariatric surgery or initiated a GLP-1

If retatrutide gains adult approval in 2026 or 2027 (Phase 3 results from the TRIUMPH program are expected in 2025 to 2026), an adolescent trial could begin enrollment by 2028 at the earliest, with results by 2030

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Both are effective GLP-1 medications