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Over decades of life, this progressive shortening leads to critically short telomeres, which trigger cellular senescence or apoptosis and contribute to the tissue dysfunction and organ decline associated with aging
Other relevant interactions: Colchicine (used for gout) may affect B12 absorption with long-term use Chloramphenicol (rarely used antibiotic) may blunt the haematological response to B12 treatment Monitoring considerations: Patients taking loop or thiazide diuretics require careful monitoring when initiating B12 therapy in severe deficiency, due to the risk of hypokalaemia during rapid cell production
PR Newswire (2025) 12
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