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This is supported by the observations that: (1) inorganic Hg accumulation in the proximal tubule region of the nephron is mainly handled by filtrationreabsorption as glutathione-Hg conjugates 5,6 , and (2) the renal uptake of glutathione-Hg conjugates occurs mainly at the luminal membrane via a molecular mimicry mechanism using animo acid transporters 9,12
If an underlying condition is responsible (liver disease, kidney disease, myeloproliferative disorder, or cancer), treating the underlying condition is the priority
It is derived from silica
G., Di Bisceglie, A
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