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When stimulated by profibrotic factors like TGF-1 and PDGF, pericytes readily transform into myofibroblasts, accelerating fibrosis, as demonstrated in the mouse model of unilateral ureteral obstruction (UUO) [23,24,25]
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These findings represent just a glimpse into how weight loss drugs can disrupt the market for existing treatments
This work was supported by the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Young Scientists (B) Grant Number JP15K19036 (SH), JSPS Grant-in-Aid for Young Scientists Grant Number JP19K16271 (SH), Japan Science and Technology Agency (JST) ACT-X Grant Number JPMJAX201A (SH), RIKEN FY2018 Incentive Research Projects (SH), and Naito Grant for female scientists after maternity leave (SH)
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