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[64], treatment with acetyl-l-carnitine (500 mg twice daily intramuscularly for 10 days followed by 2000 mg daily administered orally for 355 days) resulted in improvement in neurophysiological parameters and pain reduction over a 1-year period [64]
3.3 The role of stress and mental health Chronic stress and mental health disorders such as depression, cognitive impairment, psychological distress, and anxiety have been increasingly implicated in the progression and worsening of CKD, with the gut-brain axis playing a central role in this connection (Gela et al., 2024)
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