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The starting dose (0.25 mg semaglutide or 2.5 mg tirzepatide) is a titration dose, not a therapeutic dose

Avoid injecting into areas of active inflammation, bruising, or tenderness from previous doses

Lancet 382:339352 Thomas MC, Cooper ME, Zimmet P (2016) Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease

Because these adverse reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure